ARTERIAL GIPERTENZIYANI DAVOLASHDA ENALAPRILNING SAMARADORLIGI
Keywords:
Enalapril, arterial gipertenziya, aldosteron, qon bosimiAbstract
Enalapril — angiotenzin aylantiruvchi ferment (AAF) ingibitori bo‘lib, u renin-angiotenzin-aldosteron tizimini (RAAS) bloklash orqali o‘zining terapevtik ta’sirini namoyon etadi [2]. Preparat angiotenzin II hosil bo‘lishini kamaytiradi, natijada periferik qon tomirlari kengayadi, umumiy periferik qarshilik pasayadi va arterial qon bosimi barqaror ravishda tushadi [7]. Shu bilan birga, aldosteron sekretsiyasining kamayishi natriy va suv chiqarilishini kuchaytiradi, bu esa hajmga bog‘liq gipertenziya komponentini ham nazorat qiladi [1]. Bundan tashqari, bradikinin parchalanishining sekinlashuvi qo‘shimcha vazodilatatsion effekt beradi [4]. Enalaprilning samaradorligi ko‘plab klinik tadqiqotlarda isbotlangan bo‘lib, u sistolik va diastolik qon bosimini ishonchli darajada pasaytiradi, yurakning chap qorincha gipertrofiyasini regressiyaga uchratadi hamda yurak-qon tomir asoratlari xavfini kamaytiradi [6]. Ayniqsa, yurak yetishmovchiligi yoki diabetik nefropatiya bilan kechuvchi gipertenziyada preparatning nefroprotektiv va kardioprotektiv xususiyatlari alohida ahamiyat kasb etadi [3]. Enalapril uzoq muddatli qo‘llanganda prognozni yaxshilashi, ya’ni bemorlarning yashash davomiyligini oshirishi bilan ham muhimdir [5].
References
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4.Jameson JL, Fauci AS, et al. Harrison’s Principles of Internal Medicine, 20th ed., McGraw-Hill, 2018. – Chapter on ACE inhibitors.
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