O’ZBEKISTON AYOLLARIDA GINEKOLOGIK YALLIG’LANISH KASALLIKLARIDA STAPHYLOCOCCUS HEMOLITICUSNING MIKROBIOLOGIK XUSUSIYATLARI VA ANTIBIOTIKLARGA SEZUVCHANLIGI
Keywords:
Staphylococcus haemolyticus, ginekologik yallig‘lanish kasalliklari, mikrobiologik xususiyatlar, antibiotiklarga sezuvchanlik, antibiotik rezistentligi, biofilm, opportunistik infeksiya, ayollar salomatligi, vaginal mikrobiotsenoz, disbiozAbstract
Mazkur maqolada O‘zbekiston ayollari orasida uchraydigan ginekologik yallig‘lanish kasalliklarida Staphylococcus haemolyticusning mikrobiologik xususiyatlari, patogenlik omillari hamda antibiotiklarga sezuvchanlik darajasi o‘rganilgan. So‘nggi yillarda ushbu mikroorganizmlar shartli-patogen flora vakili sifatida klinik ahamiyat kasb etib, ginekologik infeksiyalarning etiologik tarkibida muhim o‘rin egallamoqda.
Tadqiqot natijalari Staphylococcus haemolyticusning biofilm hosil qilish qobiliyati, genetik moslashuvchanligi va ko‘p dorilarga chidamliligi yuqori ekanligini ko‘rsatadi. Bu esa infeksion jarayonlarning surunkali kechishi va davolash samaradorligining pasayishiga olib keladi.
Shuningdek, mikroorganizmlarning antibiotiklarga sezuvchanlik profili o‘zgaruvchan bo‘lib, individual yondashuv asosida davolash strategiyasini tanlash zarurligini ta’kidlaydi. Mazkur tadqiqot natijalari ginekologik infeksiyalarni diagnostika qilish va samarali davolash usullarini takomillashtirishda muhim ahamiyatga ega.
References
1. Workowski K.A., Bachmann L.H., Chan P.A., Johnston C.M., Muzny C.A., Park I., Reno H., Zenilman J.M., Bolan G.A.Sexually transmitted infections treatment guidelines, 2021.
2. MMWR Recomm Rep. 2021;70(4):1–187.doi:10.15585/mmwr.rr7004a1
3. Becker K., Heilmann C., Peters G.Coagulase-negative staphylococci.
4. Clin Microbiol Rev. 2014;27(4):870–926.doi:10.1128/CMR.00109-13
5. Otto M.Staphylococcus epidermidis — the “accidental” pathogen.Nat Rev Microbiol. 2009;7(8):555–567.doi:10.1038/nrmicro2182
6. Heilmann C., Ziebuhr W., Becker K.Are coagulase-negative staphylococci virulent?
7. Clin Microbiol Infect. 2019;25(9):1071–1080.doi:10.1016/j.cmi.2018.11.012
8. Widerström M., Wiström J., Sjöstedt A., Monsen T.Coagulase-negative staphylococci as pathogens.Eur J Clin Microbiol Infect Dis. 2012;31(8):1819–1827.doi:10.1007/s10096-011-1457-0
9. T.Coagulase-negative staphylococci as pathogens.Eur J Clin Microbiol Infect Dis. 2012;31(8):1819–1827.doi:10.1007/s10096-011-1457-0
10. .Barros E.M., Lemos M., Souto-Padrón T., Giambiagi-deMarval M.Phenotypic and genotypic characterization of Staphylococcus haemolyticus isolates from clinical sources.
11. J Med Microbiol. 2012;61(6):815–822. doi:10.1099/jmm.0.040451-0
12. .Czekaj T., Ciszewski M., Szewczyk E.M.Staphylococcus haemolyticus – an emerging threat in the hospital environment.
13. Antibiotics (Basel). 2015;4(3): 362–379. doi:10.3390/antibiotics4030362
14. .Fredheim E.G.A., Klingenberg C., Rohde H., Frankenberger S., Gaustad P., Flaegstad T. Sollid J.E.B.Biofilm formation by Staphylococcus haemolyticus.
15. J Clin Microbiol. 2009;47(4):1172–1180. doi:10.1128/JCM.01891-08
16. Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A.Whole-genome sequencing of Staphylococcus haemolyticus reveals extensive drug resistance.
17. Genome Res. 2005;15(10): 1401–1410. doi:10.1101/gr.3572305
18. Zhang Y., He X., Ding Y., Li H., Lu Q.Antimicrobial resistance and molecular epidemiology of Staphylococcus haemolyticus in clinical isolates.
19. BMC Infect Dis. 2013;13: 292. doi:10.1186/1471-2334-13-292
20. Piette A., Verschraegen G.Role of coagulase-negative staphylococci in human disease.
21. Vet Microbiol. 2009;134(1–2):45–54. doi:10.1016/j.vetmic.2008.09.009
22. .Koksal F., Yasar H., Samasti M.Antibiotic resistance patterns of coagulase-negative staphylococci isolated from blood cultures.
23. Microbiol Res. 2009;164(4):404–410. doi:10.1016/j.micres.2007.03.004
