YOSH CHEKUVCHILARDA BRONXOADENOKARSINOMA KASALLIGI
Keywords:
Bronxoadenokarsinoma, o‘pka adenokarsinomasi, yosh chekuvchilar, tamaki chekish, elektron sigaretalar, nikotin mahsulotlari, epidemiologiya, molekulyar mutatsiyalar (EGFR, ALK, ROS1), oksidativ stress, onkologik kasalliklar, erta diagnostika, skrining, maqsadli terapiyaAbstract
mazkur ishda yosh chekuvchilar orasida bronxoadenokarsinoma (o‘pka adenokarsinomasi) kasalligining tarqalish tendensiyalari, etiologik omillari va patogenetik mexanizmlari tahlil qilingan. Tadqiqotda zamonaviy epidemiologik ma’lumotlar asosida ushbu kasallikning nafaqat keksa yoshdagilar, balki yosh populyatsiya orasida ham ortib borayotgani ko‘rsatib berilgan. Ayniqsa tamaki chekish, elektron sigaretalar va boshqa nikotin yetkazib beruvchi vositalarning keng tarqalishi kasallik rivojlanishida muhim xavf omili sifatida baholangan.
Shuningdek, EGFR, ALK va ROS1 kabi molekulyar o‘zgarishlarning o‘sma rivojlanishidagi roli yoritilgan. Yosh bemorlarda kasallikning ko‘pincha kech bosqichlarda aniqlanishi, diagnostika va skrining muammolari ham muhokama qilingan. Natijada, kasallikning oldini olish, erta aniqlash va zamonaviy maqsadli terapiya usullarini qo‘llash zarurligi asoslab berilgan.
References
1.Travis W.D., Brambilla E., Nicholson A.G. et al.The 2021 WHO classification of lung tumors: impact of advances since 2015.J Thorac Oncol. 2021;16(7):1001–1020.doi:10.1016/j.jtho.2021.02.019
2. Herbst R.S., Morgensztern D., Boshoff C.The biology and management of non-small cell lung cancer.Nature. 2018;553(7689):446–454.doi:10.1038/nature25183
3. Sung H., Ferlay J., Siegel R.L. et al.Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide.CA Cancer J Clin. 2021;71(3):209–249.doi:10.3322/caac.21660
4. World Health Organization (WHO).Tobacco and cancer fact sheet.
WHO; 2023.
5. Gotts J.E., Jordt S.E., McConnell R., Tarran R.What are the respiratory effects of e-cigarettes?BMJ. 2019;366:l5275.doi:10.1136/bmj.l5275
6. International Agency for Research on Cancer (IARC).GLOBOCAN 2022: Lung cancer fact sheet.Lyon: IARC; 2022.
7. World Health Organization.Cancer Country Profile: Uzbekistan.WHO; 2022–2023.
8. Global Cancer Statistics 2020
9. World Health Organization (Who).
10. Herbst R.S.Morgensztern D.Boshoff C.The Biology And Management Of Nsclc. Nature. 2018
11. International Agency For Research On Cancer (Iarc). Globocan 2022
